deep brain stimulation and gene expression alterations in parkinson’s disease

Deep Brain Stimulation and Gene Expression Alterations in Parkinson’s Disease

Deep Brain Stimulation and Gene Expression Alterations in Parkinson’s Disease

*Corresponding author: A. Mohammadi, Ph.D; Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran E-mail: ar.mohammadi@ bmsu.ac.ir Parkinson disease (PD) is a neurobiological disorder caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is typically characterized by features including rigidity, tremor, stiffness, and bradyk...

Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients

OBJECTIVE Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD Eleven PD patients performed VF tasks in their STN DBS ON and OFF conditio...

O10: Deep Brain Stimulation and Psychiatry

The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, Gilles de la Tourette’s syndrome and major depression. This presentat...

o10: deep brain stimulation and psychiatry

the use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. currently deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, gilles de la tourette’s syndrome and major depression. this presentat...

Deep Brain Stimulation in Parkinson’s Disease

In some regards, the surgical procedures for the different targets are similar. The target can be located using a combination of imaging (MRI, C T, ventriculography, depending on the centre) and electrophysiology (electrical stimulation and, in some centres, microrecordings). Implantation of the electrode is generally performed under local anaesthesia to allow the evaluation of the effect of th...